Validity and responsiveness of presenteeism scales in chronic work-related upper-extremity disorders.

BACKGROUND: The Work Limitations Questionnaire-25 (WLQ-25) and the Work Instability Scale for Rheumatoid Arthritis (RA-WIS) have been used to measure at-work disability related to musculoskeletal disorders. However, a recent systematic review has shown that important psychometric properties still needed to be evaluated. OBJECTIVE: The purpose of this study was to establish the validity and responsiveness of the WLQ-25 and RA-WIS in people with chronic work-related upper-extremity disorders. DESIGN: Two-hundred six participants with chronic upper-extremity disorders who attended a specialty clinic operated by the Workplace Safety & Insurance Board of Ontario were evaluated at their initial visit and 6 months later. METHODS: Questionnaires completed at each evaluation were: the WLQ-25, the RA-WIS, the QuickDASH, the pain subscale of the Shoulder Pain and Disability Questionnaire, and the Chronic Pain Grade Questionnaire. At the 6-month evaluation, participants completed a global rating of change question. Known-group and construct convergent validity were assessed using analysis of variance and Pearson correlations, and standardized response means (SRMs) were used to assess responsiveness. Clinically important differences (CIDs) also were determined. RESULTS: The WLQ-25 and RA-WIS had low to moderate correlations with pain and disability scales (.28

Perilunate injuries.

Perilunate injuries are complex injuries of the bony and ligamentous structures of the wrist. They require operative management with careful restoration of carpal alignment and open reduction and internal fixation of associated fractures. Even with optimal treatment, mild to moderate dysfunction affects most patients.

Perilunate injuries.

Perilunate injuries are complex injuries of the bony and ligamentous structures of the wrist. They require operative management with careful restoration of carpal alignment and open reduction and internal fixation of associated fractures. Even with optimal treatment, mild to moderate dysfunction affects most patients.

Surgical approaches to the distal radioulnar joint.

The distal radioulnar joint (DRUJ) is classified as a uniaxial synovial pivot joint between the convex head of the ulna and the concave ulnar notch of the radius. The DRUJ can be approached from 3 sides with a refined dorsal approach retaining a robust retinacular-dorsal capsular layer preferred by most surgeons. Recent descriptions of safe and extensile volar approaches have broadened indications for a volar approach to the DRUJ. A subcutaneous ulnar approach remains an option particularly when dealing with additional distal ulnar pathology. A description of technique and review of the surgical experience in exposure and treatment of DRUJ pathology will be presented, with advantages, disadvantages, and authors' preferred techniques.

Assessment of thumb metacarpophalangeal joint arthrodesis using a single longitudinal K-wire.

PURPOSE: To evaluate retrospectively the functional and radiographic outcome of patients who had a thumb metacarpophalangeal joint arthrodesis with a single longitudinal K-wire. METHODS: We performed a retrospective review of 27 patients who had a thumb metacarpophalangeal joint arthrodesis with a single longitudinal K-wire. Outcomes were assessed using self-reported measures (Patient-Rated Wrist/Hand Evaluation; AUSCAN Osteoarthritis Hand Index; Disabilities of the Arm, Shoulder and Hand questionnaire; Short Form-36 General Health questionnaire), measured physical impairments (range of motion, strength, manual dexterity), and radiographic review. RESULTS: Patient-rated outcome scores indicated mild pain, difficulty with specific and usual tasks, and minimal concern with hand appearance. Most physical impairment measures were not significantly different from the side not surgically treated, and patient satisfaction was high. There was a slight decrease in tripod pinch strength, manual dexterity, interphalangeal joint flexion, handspan, and thumb opposition compared with the contralateral side. The overall complication rate was 11% (3 complications). Twenty-five patients (89%) were able to return to their previous occupations. There were no radiographic malunions or nonunions. Radiographic evidence of degenerative changes was present in 20% of patients at the carpometacarpal joint and 30% of patients at the interphalangeal joint. CONCLUSIONS: Our technique of performing a thumb metacarpophalangeal joint arthrodesis with a single longitudinal K-wire is effective, with high overall patient satisfaction and a relatively low complication rate, despite small losses of strength, manual dexterity, and motion. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.

Predictors of time lost from work following a distal radius fracture.

STUDY DESIGN: Prospective Cohort. OBJECTIVE: to describe time lost from work following a distal radius fracture. METHOD: A cohort of 227 workers with distal radius fracture was enrolled at a baseline visit to the hand clinic where injury, patient characteristics, and occupational demand were recorded. Patients were followed up at 2, 3, 6, and 12 months and self-reported time lost from work, disability (PRWE, DASH), and health (SF-36). Impairments of grip strength, wrist motion and dexterity were measured at 2 and 3 months post-fracture. Measurements of fracture displacement and post-treatment anatomic position were obtained from available radiographs (n = 101). Bivariate/stepwise multiple linear regression and ANOVA were used to explore factors that affect work loss. RESULTS: The average number of weeks lost from work was 9.2 (SD = 9.7; range = 0-52, median = 8); although 21% of participants reported no lost time. Post-treatment or follow-up radiographic measures were not related to time lost from work. Self-reported disability and occupational demands were the strongest predictors of time lost. Models with self-reported disability produced higher R2 than those with physical impairment (40% vs. 29%), although some independent effects of both were evident (R2 = 43%). Significant bivariate predictors like educational level and worker's compensation were excluded in multivariate models that included occupational demand. CONCLUSIONS: Work loss following DRF is highly variable and cannot be accurately predicted solely on the basis of clinical variables. Patients who have high self-reported pain/disability and occupational demand at baseline are at risk of prolonged work loss.

Outcomes in carpal tunnel syndrome: symptom severity, conservative management and progression to surgery.

PURPOSE: This study investigated the relationship between severity of symptoms and success of nonoperative and operative treatment in patients with carpal tunnel syndrome (CTS). METHODS: An observational cohort study regarding the management of CTS was conducted. Thirty patients referred to a tertiary hand centre with a diagnosis of CTS were prospectively followed. Twenty-five of the patients (47 affected hands) were available for long-term follow up to determine management outcomes. Self-report symptoms and physical impairments were assessed and documented at baseline, 6 weeks, and 12 weeks using the CTS Severity Score (SSS), the Disability-Shoulder, Arm and Hand Score (DASH), and the Levine Functional Score. Longer-term follow-up was conducted to identify status on outcome measures and whether patients proceeded to surgery. RESULTS: Those who proceeded to surgery (n = 27/47 hands) had higher initial CTS SSS and DASH scores and also maintained higher scores compared to those who improved with conservative management (p < 0.05). Improvements occurred in the SSS (P < 0.0001), Functional Score (P < 0.001), and DASH score (P < 0.05) following surgery in the patients resistant to conservative management. Recovery of grip and dexterity was less satisfactory. DISCUSSION: This study suggests that the SSS is useful in the triage of patients on surgical wait-lists as patients with high initial scores or failure to change in short-term follow-up are likely to proceed to surgical release. Despite prolonged symptoms and previous treatment, patients with lower SSS scores had moderate success with a second trial of conservative management.

Individual finger strength: are the ulnar digits "powerful"?

This study determined the test-retest reliability of a grip device that measures the contribution of individual fingers to grip strength and described the pattern of contribution in subjects without hand pathology. Subjects repeated a set of three maximal grip efforts on two occasions separated by two to seven days. Intraclass correlation reliability coefficients were high (>0.75) for eight out of ten strength measures. The percentage contributions of the index, middle, ring, and small fingers to grip were approximately 25%, 35%, 25%, and 14%, respectively. Grip and finger strengths were highly correlated. Anthropometric measures of body size or finger length were moderately correlated with strength measures. These data suggest that there is a predictable pattern by which individual fingers contribute to overall grip strength, which is partially related to body size. The ulnar side of the hand contributes to the smaller proportion of overall grip (approximately 60% radial, 40% ulnar). The clinical utility of finger strength measures should be explored.

Wound healing-associated proteins Hsp47 and fibronectin are elevated in Dupuytren's contracture.

BACKGROUND: Dupuytren's contracture or disease (DD) affects hand function by causing irreversible contraction of the palmar fascia. Histological analysis has shown that DD and wound granulation tissue share many cellular and biochemical characteristics, suggesting that DD may be an exaggerated wound-healing response. The goal of the present study was to examine the possible involvement of two important wound-healing-associated proteins-heat shock protein 47 (Hsp47), fibronectin (Fn), and its oncofetal isoforms-in DD, using clinical tissue samples and primary cell cultures. MATERIALS AND METHODS: We examined the expression of Hsp47, Fn, and an oncofetal isoform of fibronectin (IIICS) in both normal and disease-matched surgical specimens and primary cell cultures using Western blot analysis, and immunocytochemistry (ICC). RESULTS: Our results indicate that Hsp47 and total fibronectin is elevated in DD lesional tissue. In addition, Western and ICC analysis of patient-matched (normal and disease) primary cultures show significantly elevated levels of oncofetal fibronectin (IIICS spliced variant) within disease primary cell cultures. CONCLUSIONS: The high levels of expression of Hsp47 and adult and oncofetal fibronectin in DD suggests that cell-mediated alterations in the extracellular environment may play an important role in the disease process. Furthermore, the involvement of these wound healing-associated proteins in DD supports the notion that this disease may be an exaggerated form of wound healing.

Extensor quadriga: Pathomechanics and treatment.

The extensor tendons to the index, long, ring and small fingers are motored by the common extensor digitorum communis muscle body. Effective function of this muscle can only occur if the gliding amplitude of each of its four extensor tendons is normal. As a corollary, limitation of the excursion of any of the individual tendons by adhesions at a fracture or tendon repair site, a fixed flexion contracture at the metacarpophalangeal joint, or by rupture, attenuation or laceration of a saggital band or juncturae tendinum, will result in reduction of the excursion of the adjacent extensor tendons. This pathological state has been termed the extensor quadriga because of its similarities to the analogous pathology affecting the flexor digitorum profundus system. Improper management of this clinical entity may lead to an abnormal pathomechanical kinematic chain imbalance. Early identification and treatment is critical to address this entity appropriately.

Les tendons extenseurs de l'index, du majeur, de l'annulaire et de l'auriculaire sont mus par le muscle extenseur commun des doigts. Mais celuici ne peut fonctionner adéquatement que si l'amplitude de glissement de chacun des quatre tendons extenseurs est normale. En corollaire, une restriction de mouvement de l'un ou l'autre des quatre tendons, due à des adhérences en un foyer de fracture ou au siège de réparation d'un tendon, à une contracture fixe en flexion à une articulation métacarpo-phalangienne ou encore à une rupture, à une faiblesse ou à une lacération d'un ligament sagittal ou du tendon commun, entraîne une restriction de mouvement des tendons extenseurs adjacents. On a donné à ce syndrome le nom de « quadrige des extenseurs ¼ en raison de ses ressemblances avec un syndrome analogue qui touche le muscle fléchisseur commun profond des doigts. Un traitement inapproprié de ce trouble clinique peut conduire à un déséquilibre de la chaîne cinématique pathomécanique. Aussi est-il crucial de reconnaître et de traiter précocement ce syndrome afin d'en assurer une prise en charge adéquate.

Pain and disability reported in the year following a distal radius fracture: a cohort study.

BACKGROUND: Distal radius fractures are a common injury that cause pain and disability. The purpose of this study was to describe the pain and disabilities experienced by patients with a distal radius fracture in the first year following fracture. METHODS: A prospective cohort study of 129 patients with a fracture of the distal radius was conducted. Patients completed a Patient-rated Wrist Evaluation at their baseline clinic visit and at 2, 3, 6 and 12 months following their fracture. The frequency/severity of pain and disabilities reported was described at each time point. RESULTS: The majority of patients experienced mild pain at rest and (very) severe high levels of pain with movement during the first two-months following distal radius fracture. This time is also associated with (very) severe difficulty in performing specific functional activities and moderate to severe difficulty in four domains of usual activity. The majority of recovery occurred within six-months, but symptoms persisted for a small minority of patients at one-year following fracture. Patients had the most difficulty with carrying ten pounds and pushing up from a chair. Resumption of usual personal care and household work preceded, and was more complete, than work and recreational participation. CONCLUSIONS: This study demonstrated that the normal course of recovery following a distal radius fracture is one where severe symptoms subside within the first two-months and the majority of patients can be expected to have minimal pain and disability by six-months following fracture. This information can be used when planning interventions and assessing whether the progress of a patient is typical of other patients.

Elevated levels of beta-catenin and fibronectin in three-dimensional collagen cultures of Dupuytren's disease cells are regulated by tension in vitro.

BACKGROUND: Dupuytren's contracture or disease (DD) is a fibro-proliferative disease of the hand that results in the development of scar-like, collagen-rich disease cords within specific palmar fascia bands. Although the molecular pathology of DD is unknown, recent evidence suggests that beta-catenin may play a role. In this study, collagen matrix cultures of primary disease fibroblasts show enhanced contraction and isometric tension-dependent changes in beta-catenin and fibronectin levels. METHODS: Western blots of beta-catenin and fibronectin levels were determined for control and disease primary cell cultures grown within stressed- and attached-collagen matrices. Collagen contraction was quantified, and immunocytochemistry analysis of filamentous actin performed. RESULTS: Disease cells exhibited enhanced collagen contraction activity compared to control cells. Alterations in isometric tension of collagen matrices triggered dramatic changes in beta-catenin and fibronectin levels, including a transient increase in beta-catenin levels within disease cells, while fibronectin levels steadily decreased to levels below those seen in normal cell cultures. In contrast, both fibronectin and beta-catenin levels increased in attached collagen-matrix cultures of disease cells, while control cultures showed only increases in fibronectin levels. Immunocytochemistry analysis also revealed extensive filamentous actin networks in disease cells, and enhanced attachment and spreading of disease cell in collagen matrices. CONCLUSION: Three-dimensional collagen matrix cultures of primary disease cell lines are more contractile and express a more extensive filamentous actin network than patient-matched control cultures. The elevated levels of beta-catenin and Fn seen in collagen matrix cultures of disease fibroblasts can be regulated by changes in isometric tension.

Beta-catenin expression in Dupuytren's disease: potential role for cell-matrix interactions in modulating beta-catenin levels in vivo and in vitro.

Dupuytren's disease (DD) is a superficial fibromatosis of the hand. Although the molecular mechanisms responsible for this disease are unknown, recent studies suggest that beta-catenin may be a key factor involved in fibromatosis. In this study, we analysed the in vivo and in vitro expression levels of beta-catenin in DD, using surgical specimens and primary cell lines. Although no somatic mutations (exon 3) of beta-catenin were detected, Western blot analysis revealed high levels of beta-catenin in diseased palmar fascia, and low to undetectable levels of beta-catenin in patient-matched normal palmar fascia. Immunohistochemistry analysis showed high levels of beta-catenin expression within the disease fascia, as well as cytoplasmic and nuclear accumulations of the protein. Immunoprecipitation of beta-catenin from seven patient lesions showed the protein to be tyrosine phosphorylated. Lastly, Western analysis of three patient-matched (disease and normal fascia) primary cell cultures showed significantly elevated levels of beta-catenin in disease cells cultured in three-dimensional collagen lattices. This is the first extensive in vivo and in vitro characterization of beta-catenin in DD, and the first to suggest that the extracellular matrix may play an important role in modulating beta-catenin stability in DD.

Endoscopic versus open carpal tunnel release: a randomized trial.

PURPOSE: This study compared the outcomes in patients assigned to either endoscopic carpal tunnel release (ECTR) or traditional open carpal tunnel release (OCTR). METHODS: An unbalanced randomized clinical trial (91 endoscopic, 32 open) was conducted. Short-term and long-term outcomes were evaluated by a blinded assessor. The primary outcome measures were symptom severity measured on a self-report scale and nerve/vascular complications. Secondary outcomes included the McGill pain questionnaire, grip strength, pinch strength, sensory threshold (NK PSSD device, NK Biotechnical Corp, Minneapolis, MN), and time to return to work. RESULTS: Both groups improved on all outcomes. No differences were observed in primary outcomes between the groups at either baseline or follow-up at 1 week, 6 weeks, or 12 weeks after surgery. No significant complications occurred in either group. Grip strength and pain were significantly better at 1 and 6 weeks in the endoscopic group although differences dissipated by 12 weeks. No significant differences occurred in other secondary outcomes. Long-term satisfaction was lower in the endoscopic group, attributable to a 5% rate of re-operation. Lower rates of endoscopic release have occurred at our center once these results were available to surgeons and patients. CONCLUSIONS: No substantive difference in benefit was shown for these 2 methods of carpal tunnel release.

Trapezial arthroplasty with silicone rubber implantation for advanced osteoarthritis of the trapeziometacarpal joint of the thumb.

INTRODUCTION: Arthritis in the trapeziometacarpal joint of the thumb can cause swelling and loss of motion. Treatment options include arthrodesis, replacement arthroplasty and interposition arthroplasty. Our objective in this clinical study was to determine outcomes after trapezial arthroplasty with a silicone rubber implant and the relationship between self-reported and measured outcomes. METHODS: At the Hand and Upper Limb Centre, St. Joseph's Hospital, London, Ont., a tertiary care centre, we reviewed a series of 26 patients with advanced osteoarthritis who underwent silicone rubber trapezial arthroplasty. The follow-up averaged 6.5 years. We assessed the outcomes subjectively, and by clinical, functional and radiographic examination. RESULTS: Although 88% of patients reported some improvement in pain and satisfaction, when quantified the improvement was less impressive: only 5.7 (on a visual analogue scale of 1-10, poor-excellent) for pain and 5.6 for satisfaction. Superior subjective results were reported by patients older than 60 years. Osteoarthritic changes had caused pronounced functional impairment in the hands of patients who underwent surgery and those who did not, so that any long-term benefit of surgery was not measurable. Patients had difficulty manipulating both small and large objects on the Jebsen's hand function test. Peri-implant and carpal radiographic lytic changes were observed in 90% of patients. Six patients (20%) required revision surgery (3 early, 3 late), including 1 with a pathologic scaphoid fracture. CONCLUSIONS: Although clinical, functional and radiographic results were poor, they did not predict either satisfaction or pain improvement reported by patients, illustrating the need for a comprehensive standardized outcome evaluation to make informed decisions on the value of surgical intervention for osteoarthritis of the trapeziometacarpal joint.

Patient versus injury factors as predictors of pain and disability six months after a distal radius fracture.

A prospective cohort of 120 patients with distal radius fractures completed a baseline evaluation that determined their age, sex, education level, injury compensation status, AO fracture type, prereduction radial shortening, and postreduction radial shortening. Six months later patients self-reported pain and disability using the Patient-Rated Wrist Evaluation, and were tested for physical impairment (grip, wrist range of motion, and dexterity). Univariate and forward stepwise regression analyses agreed that the most influential predictor of pain and disability at 6 months was injury compensation. Patient education level and prereduction radial shortening also contributed predictive information (R squared = 25%). Wrist impairment was moderately correlated with patient reported pain and disability (r = 0.50). Both impairment and disability measures are required to fully describe outcomes. Further work is required to delineate additional factors that contribute to outcome.

Validity of pain and motion indicators recorded on a movement diagram of shoulder lateral rotation.

This study examined criterion and construct validity of passive range of motion (PROM) and pain variables recorded on a Maitland-style movement diagram. Passive lateral rotation of the shoulder was assessed in 34 patients with a variety of shoulder pathologies. Two experienced manipulative physiotherapists performed the testing in a randomised block design. The physiotherapists were blinded to all clinical information and ROM measures. The criterion comparators were a blinded goniometric measure of PROM and pain scores from the Shoulder Pain and Disability Index (SPADI). Correlation coefficients between PROM recorded on the movement diagram and goniometry were high (r = 0.79 to 0.94). Moderate correlations were observed between the patient's pain scores recorded on the SPADI and the physiotherapist's recording of pain onset (r = -0.43 to 0.69) and intensity (r = 0.58 to 0.72). Impairment measures from the movement diagram were moderately related to patient-rated shoulder disability (r = 0.50 for ROM and -0.56 for pain). Movement diagrams of passive shoulder rotation can provide valid information on motion and pain.